Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis
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چکیده
منابع مشابه
Cognitive deficits in single App knock-in mouse models
Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To overcome this issue, mice with single humanized App knock-in (KI) carrying Swedish (NL), Beyreuther/Iberian (F), and Arctic (G) mutations in different combinations were recently developed. The validity of these mouse models...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2018
ISSN: 1471-2202
DOI: 10.1186/s12868-018-0446-8