Colon Stem Cell and Crypt Dynamics Exposed by Cell Lineage Reconstruction
نویسندگان
چکیده
منابع مشابه
Colon Stem Cell and Crypt Dynamics Exposed by Cell Lineage Reconstruction
Stem cell dynamics in vivo are often being studied by lineage tracing methods. Our laboratory has previously developed a retrospective method for reconstructing cell lineage trees from somatic mutations accumulated in microsatellites. This method was applied here to explore different aspects of stem cell dynamics in the mouse colon without the use of stem cell markers. We first demonstrated the...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2011
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1002192