Colony-stimulating factor 1 regulates CTP: phosphocholine cytidylyltransferase mRNA levels.
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چکیده
منابع مشابه
CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane.
PC is the most abundant phospholipid in eukaryotic membranes whereas few prokaryotes contain PC. PC is synthesized in eukaryotes by two routes: the CDP-choline pathway (1) and PE methylation (2). PE methylation is the most important contributor to PC formation in Saccharomyces cerevisiae (3). In contrast, mammalian cells and tissues predominantly use the CDP-choline pathway (2, 4). PC is the ma...
متن کاملRegulation of CTP: phosphocholine cytidylyltransferase activity in type II pneumonocytes.
Phosphatidylcholine synthesis by rat type II pneumonocytes was altered either by depleting the cells of choline or by exposing the cells to extracellular lung surfactant. Effects of these experimental treatments on the activity of a regulatory enzyme, CTP:phosphocholine cytidylyltransferase, were investigated. Although choline depletion of type II pneumonocytes resulted in inhibition of phospha...
متن کاملIdentification of phosphorylation sites in rat liver CTP: phosphocholine cytidylyltransferase.
CTP:phosphocholine cytidylyltransferase (CT) is an important regulatory enzyme in phosphatidylcholine biosynthesis. The enzyme exists as a soluble, inactive form that is highly phosphorylated; activation of the enzyme is accompanied by dephosphorylation and translocation to the membrane. We have used a recombinant baculovirus clone to obtain CT labeled in vivo with 32PO4. The tryptic phosphopep...
متن کاملRegulation of CTP: phosphocholine cytidylyltransferase in HepG2 cells: effect of choline depletion on phosphorylation, translocation and phosphatidylcholine levels.
We studied the effect of choline depletion on the biosynthesis of phosphatidylcholine (PC) and the distribution and phosphorylation of cytidylyltransferase (CT) in HepG2 cells. Phosphocholine concentrations decreased within 24 h of choline depletion to values less than 2% of controls. The incorporation of [3H]glycerol into PC was reduced in choline-depleted (CD) cells. The apparent turnover of ...
متن کاملCDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke.
Phosphatidylcholine (PtdCho) is a major membrane phospholipid, and its loss is sufficient in itself to induce cell death. PtdCho homeostasis is regulated by the balance between hydrolysis and synthesis. PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD). PtdCho synthesis is rate-limited by CTP:phosphocholine cytidylyltransfera...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1991
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)55286-8