Combination of anthocyanin ternatin and hydroxyapatite/β-tricalcium phosphate coralline as a socket preservation biomaterial in dental implant: A narrative review

Background: Tooth extraction is surgical treatment with clinical manifestation alveolar bone resorption of 11-63% which potentially fails dental implant treatment. Socket preservation regeneration to minimize morphological changes in post-extraction using graft. Anti-inflammatory biomaterial needed modulate inflammatory cascade the lesion. Anthocyanin ternatin a flavonoid derived from butterfly pea (Clitoria ternatea) as an anti-inflammatory and antioxidants agent. Hydroxyapatite/β-Tricalcium Phosphate coralline (HA/β-TCP coralline) combination bioceramic material calcium carbonate heating Porites spp. coral has potential induce osteogenesis, osteoinduction, osteoconduction. Combination HA/β-TCP applied defect area dried powder form hard tissue regeneration. Purpose: To describe socket implant. Review: coraline socket. suppresses ROS iNOS then inhibit NF-kB signaling pathway. Downregulation pathway decreases TNF-α IL-1β/6 expression so RANKL inhibited. Lowering followed by upregulated Ca2+ level causes increase DKK1 PTEN Akt Wnt induced. Upregulation proteins induces BMP2/TGF-β/Smad1/5/8 activation manifest Runx2, OCN, Osx preosteoblast differentiation osteoblast increased. Conclusion: