Combination Therapy of Interferon Beta-1b and Tacrolimus: A Pilot Safety Study
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چکیده
منابع مشابه
Combination Therapy of Interferon Beta-1b and Tacrolimus: A Pilot Safety Study
Tacrolimus is a calcineurin inhibitor which works to induce immune suppression by preventing cytokine transcription and lymphocyte activation. Combining the immunomodulator interferon beta-1b (Betaseron) with the immunosuppressant tacrolimus (Prograf) may have the potential of additive therapeutic benefit through the complementary mechanisms of action of these two therapeutics. In this randomiz...
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The combination of IFN-a-2a (IFN-a) and IFN-’y-lb (IFN-y) has been found to produce more than additive cytotoxicity with fluorouracil (5-FU) in HT 29 colon cancer cells due to enhanced DNA-directed effects. We therefore studied the combination of IFNy with IFN-a, 5-FU, and leucovorin (LV) in a clinical trial. Fifty-three patients received an initial cycle of 5 million units (MU)/m2 IFN-a s.c. o...
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Introduction: The aim of this study is to assess the therapeutic efficacy and safety of a particular brand of IFN alpha (PDferon B®) in combination with ribavirin (RlBA) on Iranian patients with chronic hepatitis C (CHC). The addition of RIBA to the standard treatment with interferon (IFN) alpha led to an improvement in sustained virologic response (SVR) from less than 20% with IFN monother...
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ژورنال
عنوان ژورنال: Multiple Sclerosis International
سال: 2012
ISSN: 2090-2654,2090-2662
DOI: 10.1155/2012/935921