Combination therapy with ipilimumab and electrochemotherapy: preliminary efficacy results and correlation with immunological parameters
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چکیده
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چکیده ندارد.
Metastatic melanoma response to combination therapy with ipilimumab and vemurafenib.
Combination therapies for the treatment of metastatic melanoma are a matter of debate nowadays. We report on a stage IV metastatic melanoma patient with the BRAF V600 mutation and a large tumor burden initially treated with two cycles of ipilimumab. Due to dramatic disease progression, demonstrated on interim 18F-FDG PET/CT, vemurafenib was added in the patient's therapeutical scheme. After com...
متن کاملAssessing a novel immuno-oncology-based combination therapy: Ipilimumab plus electrochemotherapy
Melanoma is responsible for most skin cancer-related deaths and is one of the most common cancers diagnosed in young adults. In melanoma, tumors can become established by activation of the negative regulator of cytotoxic T lymphocytes (CTLs), CTL antigen-4 (CTLA-4). Ipilimumab blocks the interaction of CTLA-4 with CD80/CD86 and augments T-cell activation and proliferation. In electrochemotherap...
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Background: Induced abortion is the medical or surgical termination of pregnancy before fetal viability. It has maternal or fetal indications. The aim of the present study was to evaluate the efficacy of the combination of methotrexate and misoprostol for termination of the pregnancy in the first trimester. Methods: This analytic study was performed on 100 women at the first trimester of pregna...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2014
ISSN: 1479-5876
DOI: 10.1186/1479-5876-12-s1-o5