Combined ursodeoxycholic acid (UDCA) and fenofibrate in primary biliary cholangitis patients with incomplete UDCA response may improve outcomes
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چکیده
منابع مشابه
Ursodeoxycholic Acid (UDCA) in Biliary Diseases: A Clinical Review
Ursodeoxycholic acid (UDCA) is an established and accepted treatment of biliary diseases such as gallstones and primary biliary cirrhosis. Mechanisms of action of UDCA are not so far completely elucidated. UDCA tablets are indicated for the dissolution of small to medium sized radiolucent, cholesterol-rich gall-stones in patients with a functioning gall bladderand in the treatment of primary bi...
متن کاملMethotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis.
This placebo-controlled, randomized, multicenter trial compared the effects of MTX plus UDCA to UDCA alone on the course of primary biliary cirrhosis (PBC). Two hundred and sixty five AMA positive patients without ascites, variceal bleeding, or encephalopathy; a serum bilirubin less than 3 mg/dL; serum albumin 3 g/dL or greater, who had taken UDCA 15 mg/kg daily for at least 6 months, were stra...
متن کاملCombination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis
BACKGROUND Although the effectiveness of treatment with ursodeoxycholic acid (UDCA) and fenofibrate for primary biliary cirrhosis (PBC) has been suggested by small trials, a systematic review to summarize the evidence has not yet been carried out. METHODS A meta-analysis of all long-term randomized controlled trials comparing the combination of UDCA and fenofibrate with UDCA monotherapy was p...
متن کاملTherapeutic and Chemopreventive Effects of Ursodeoxycholic Acid (UDCA): Potential Role in Patients with Barrett’s Esophagus
Instructor, Department of Internal Medicine, University of Texas Southwestern Medical Center and Dallas VA Medical Center, Esophageal Diseases Center, Dallas, Texas 75216, USA *Corresponding author Xiaofang Huo, MD, PhD Instructor Department of Internal Medicine University of Texas Southwestern Medical Center and Dallas VA Medical Center, Esophageal Diseases Center Dallas, Texas 75216, USA E-ma...
متن کاملFenofibrate in Primary Biliary Cirrhosis: A Pilot Study
BACKGROUND Most patients with primary biliary cirrhosis (PBC) are treated with ursodeoxycholic acid (UDCA); however, some do not respond fully. PBC is also associated with dyslipidemia, but a link with vascular risk has not been confirmed. METHODS AND RESULTS In this study we compared UDCA monotherapy with fenofibrate plus UDCA in PBC patients with incomplete biochemical response to UDCA mono...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2015
ISSN: 0269-2813
DOI: 10.1111/apt.13465