Comment on ‘Jaw avascular bone necrosis associated with long-term use of biphosphonates’

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Jaw avascular bone necrosis associated with long-term use of biphosphonates.

Bisphosphonates are currently used to prevent bone complications and to treat malignant hypercalcemia in patients with multiple myeloma, or bone metastases from breast and prostate cancers [1]. Within the last year we observed 10 patients who developed jaw bone necrosis while on treatment with zoledronic acid (Zometa; Novartis) or pamidronate. All the patients had breast cancer with skeletal di...

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Letters to the Editor Jaw avascular bone necrosis associated with long-term use of biphosphonates

Bisphosphonates are currently used to prevent bone complications and to treat malignant hypercalcemia in patients with multiple myeloma, or bone metastases from breast and prostate cancers [1]. Within the last year we observed 10 patients who developed jaw bone necrosis while on treatment with zoledronic acid (Zometa; Novartis) or pamidronate. All the patients had breast cancer with skeletal di...

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The Evolution of Long-term Care Programs; Comment on “Financing Long-term Care: Lessons From Japan”

The need for long-term care (LTC) represents a “new social risk,” one that overlaps with and complements systems of care that pre-date such programs, complicating LTC program design. This commentary expands on Ikegami’s discussion of how these structural factors must be accommodated, as well as historical and cultural factors that influence public expectations of such a...

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Complications associated with treatment of malignancies: a focus on avascular necrosis of the bone.

Cancer patients have a better prognosis now than in the past. An estimated 66% of patients diagnosed with cancer between 1996 and 2004 were alive at 5 years.1 As patients are living longer after treatment, long-term complications associated with treatment are becoming a greater issue. Avascular necrosis, also referred to as osteonecrosis, ischemic necrosis, subchondral avascular necrosis, asept...

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The treatments of avascular osteonecrosis (AVN) include both conservative and surgical methods which are dependent on the stage and progression of the disease. The vasoactive-prostaglandin-analogue iloprost (PGI2) has been utilized in several areas of medicine and recently has been used for the treatment of AVN. A total of 108 patients with 136 osteonecrosis of different joints, etiology and se...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 2006

ISSN: 0923-7534

DOI: 10.1093/annonc/mdj012