Common and Distinct Mechanisms of Cognitive Flexibility in Prefrontal Cortex
نویسندگان
چکیده
منابع مشابه
Common and distinct mechanisms of cognitive flexibility in prefrontal cortex.
The human ability to flexibly alternate between tasks represents a central component of cognitive control. Neuroimaging studies have linked task switching with a diverse set of prefrontal cortex (PFC) regions, but the contributions of these regions to various forms of cognitive flexibility remain largely unknown. Here, subjects underwent functional brain imaging while they completed a paradigm ...
متن کاملDissociable mechanisms of cognitive control in prefrontal and premotor cortex.
Intelligent behavior depends on the ability to suppress inappropriate actions and resolve interference between competing responses. Recent clinical and neuroimaging evidence has demonstrated the involvement of prefrontal, parietal, and premotor areas during behaviors that emphasize conflict and inhibition. It remains unclear, however, whether discrete subregions within this network are crucial ...
متن کاملMore is less: a disinhibited prefrontal cortex impairs cognitive flexibility.
The prefrontal cortex (PFC) is critical for decision making, and it becomes dysfunctional in many neuropsychiatric disorders. Studies in schizophrenia patients and relevant animal models suggest loss of PFC inhibitory interneuron function. For instance, rats with a neonatal ventral hippocampal lesion (NVHL) show a deficient modulation of PFC interneurons by dopamine (DA). Whether the PFC become...
متن کاملFlexible neural mechanisms of cognitive control within human prefrontal cortex.
A major challenge in research on executive control is to reveal its functional decomposition into underlying neural mechanisms. A typical assumption is that this decomposition occurs solely through anatomically based dissociations. Here we tested an alternative hypothesis that different cognitive control processes may be implemented within the same brain regions, with fractionation and dissocia...
متن کاملDendritic growth in medial prefrontal cortex and cognitive flexibility are enhanced during the postpartum period.
The postpartum period is associated with numerous hormonal changes, some of which have been linked to detrimental effects on the medial prefrontal cortex (mPFC), a brain region involved in cognition. Here, we investigated whether mPFC structure and function are negatively influenced during the postpartum period, an outcome that might be predicted by the maternal hormonal milieu. Mother rats wer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2011
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.5923-10.2011