Comparative Studies on the Purification of Tetanus and Diphtheria Toxins


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Comparative Studies on the Purification of Tetanus and Diphtheria Toxins.

Diphtheria toxin has been identified as a typical heat-coagulable protein (Eaton 1936 a, 1937; Pappenheimer 1937). If other toxins have chemical properties similar to diphtheria toxin, they might be isolated by similar methods. Using a gelatin hydrolysate medium, Pappenheimer and Johnson (1936, 1937) have produced diphtheria toxin which may be obtained in a relatively pure state by simple fract...

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Pyrexia after diphtheria/tetanus/pertussis and diphtheria/tetanus vaccines.

The temperatures of 587 children were taken before and after diphtheria/tetanus/pertussis (DTP) or diphtheria/tetanus (DT) vaccine. Only slight temperature increases were found but these were notably more frequent after plain than adsorbed DTP vaccine preparations and the frequency increased with each successive dose.

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Universal epitopes for human CD4+ cells on tetanus and diphtheria toxins.

Previous studies suggested that tetanus and diphtheria toxoids (TTD and DTD, respectively) contain "universal" epitopes for human CD4+ cells (residues 632-651 and 950-969 of TTD and 271-290, 321-350, 351-370, 411-430, and 431-450 of DTD). To investigate whether CD4+ cells of 100 randomly selected subjects recognized those sequences, the proliferation of CD4+ cell-enriched blood lymphocytes to T...

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عنوان ژورنال: Journal of Bacteriology

سال: 1938

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.36.4.423-432.1938