Comparison of Once-daily versus Twice-daily Injection of Insulin Detemir in Children with Type 1 Diabetes Mellitus

Background: The purpose of this study was to compare the effectiveness once-daily versus twice-daily insulin detemir injection in children with type 1 diabetes mellitus (T1DM). Methods: In randomized 4-month clinical trial, 60 aged 33 - 156 months T1DM were randomly assigned into two groups, (group 1) and 2) pre-meal Aspart. first month devoted educating patients dose titration. Hemoglobin A1C (HbA1C) measured at end again after fourth month. Hypoglycemia as one major complications defined blood glucose lower than 70 mg/dL symptoms or 50 absence symptoms. Results: Mean HbA1C 8.5% ± 1% group 1.1% 2 (P = 0.98). changes compared baseline -0.09% (95% CI: -0.47 0.3) 1, -0.42% -0.94 0.09) 0.273). treatment modification rate 39% 15% groups 2, respectively 0.02). However, there no statistically significant differences between terms dose, hypoglycemia, other complications. Conclusions: Twice-daily injections did not change HbA1c comparison injections. age our considerable.