Comparisons between perivascular adipose tissue and the endothelium in their modulation of vascular tone
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منابع مشابه
Modulation of thiopental-induced vascular relaxation and contraction by perivascular adipose tissue and endothelium.
BACKGROUND Thiopental induces relaxation of vascular smooth muscle cells through its direct and/or indirect vasodilator effects. The perivascular adipose tissue (PVAT) and the endothelium are known to attenuate vascular contraction, and we have recently reported that PVAT potentiates the relaxation effect of propofol through endothelium-dependent and -independent mechanisms. Here, we studied th...
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15 صفحه اولPerivascular adipose tissue, vascular reactivity and hypertension.
Most blood vessels are surrounded by a variable amount of adventitial adipose tissue, perivascular adipose tissue (PVAT), which was originally thought to provide mechanical support for the vessel. It is now known that PVAT secretes a number of bioactive substances including vascular endothelial growth factor, tumor necrosis factor-alpha (TNF-α), leptin, adiponectin, insulin-like growth factor, ...
متن کاملPerivascular adipose tissue and coronary vascular disease.
Coronary perivascular adipose tissue is a naturally occurring adipose tissue depot that normally surrounds the major coronary arteries on the surface of the heart. Although originally thought to promote vascular health and integrity, there is a growing body of evidence to support that coronary perivascular adipose tissue displays a distinct phenotype relative to other adipose depots and is capa...
متن کاملRole of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension.
BACKGROUND Perivascular adipose tissue (PVAT)-derived relaxing factor (PVATRF) significantly regulates vascular tone. Its chemical nature remains unknown. We determined whether palmitic acid methyl ester (PAME) was the PVATRF and whether its release and/or vasorelaxing activity decreased in hypertension. METHODS AND RESULTS Using superfusion bioassay cascade technique, tissue bath myography, ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2016
ISSN: 0007-1188
DOI: 10.1111/bph.13648