Competitive binding of chlorinated azobenzenes to the Ah receptor protein
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چکیده
منابع مشابه
The aryl hydrocarbon (Ah) receptor transcriptional regulator hepatitis B virus X-associated protein 2 antagonizes p23 binding to Ah receptor-Hsp90 complexes and is dispensable for receptor function.
To further understand the role that the hepatitis B virus X-associated protein 2 (XAP2) plays in regulating aryl hydrocarbon receptor (AhR) function, a point mutation was introduced at tyrosine 408 of the AhR, changing the residue to an alanine or lysine. These mutations resulted in the loss of AhR binding to endogenous XAP2 in COS-1 cells and reduced binding of exogenously expressed XAP2. Cell...
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ژورنال
عنوان ژورنال: Environmental Toxicology and Chemistry
سال: 1989
ISSN: 0730-7268,1552-8618
DOI: 10.1002/etc.5620080104