Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

Complement in immune and inflammatory disorders: pathophysiological mechanisms.

Although acute or chronic inflammation is a common component of many clinical disorders, the underlying processes can be highly distinct. In recent years, the complement system has been associated with a growing number of immunological and inflammatory conditions that include degenerative diseases, cancer, and transplant rejection. It becomes evident that excessive activation or insufficient co...

Disorders: Pathophysiological Mechanisms Complement in Immune and Inflammatory

Complement in immune and inflammatory disorders: therapeutic interventions.

With the awareness that immune-inflammatory cross-talk is at the heart of many disorders, the desire for novel immunomodulatory strategies in the therapy of such diseases has grown dramatically. As a prime initiator and important modulator of immunological and inflammatory processes, the complement system has emerged as an attractive target for early and upstream intervention in inflammatory di...

Immune Issues and Mechanisms in Cancer

The immunologic defense mechanism is well demon­trated in neoplasia of animals and human. Spontaneous regression of many human tumors such as malignant melanomas, 1vmphosarcomas, neuroblastomas choriocar­cinomas, adenocarcinomas and leukemias is due to the defense mechanism of lymphoretrcular system. The discovery of carcinoembrvonicantigen in carcinoma of gastrointestinal tract and the alpha-f...

The basal ganglia and disorders of movement: pathophysiological mechanisms.

The basal ganglia are part of a neuronal network organized in parallel circuits. The "motor circuit" is most relevant to the pathophysiology of movement. Abnormal increment or reduction in the inhibitory output activity of basal ganglia give rise, respectively, to poverty and slowness of movement (i.e., Parkinson's disease) or dyskinesias.