Complement in Ischemia Reperfusion Injury

Complement in ischemia reperfusion injury.

In the current issue of The American Journal of Pathology Stahl et al describe an important role for the alternative complement pathway in ischemia reperfusion (I/R) of the intestine, using factor D-deficient mice. The requirement for the complement system in I/R-induced tissue injury has been established, but the contribution of the various complement pathways (classical, alternative, and lect...

Role of complement component C5 in cerebral ischemia/reperfusion injury.

We evaluated the role of complement component C5 during the course of cerebral ischemic reperfusion injury in a rat model of middle cerebral artery occlusion (MCAO). Systemic C5 inhibition was achieved with an anti-C5 monoclonal antibody, which significantly prevented the deterioration of the motor functions by reducing cerebral lesion and edema. Our results show that activated C5 complement co...

Role for the alternative complement pathway in ischemia/reperfusion injury.

The terminal complement components play an important role in mediating tissue injury after ischemia and reperfusion (I/R) injury in rats and mice. However, the specific complement pathways involved in I/R injury are unknown. The role of the alternative pathway in I/R injury may be particularly important, as it amplifies complement activation and deposition. In this study, the role of the altern...

Targeting Complement in Treatment of Intestinal Ischemia/Reperfusion-Induced Injury

Complement activation occurs during tissue injury and inappropriate or excessive activation contributes to the expression of pathology becoming a double-edged sword. Understanding the role of complement and its natural regulatory molecules will enable the development of therapeutic interventions to prevent excessive damage during mesenteric ischemia/reperfusion (IR). In this chapter, we will br...

Is Lectin Complement Pathway Dependent Gastrointestinal Ischemia-Reperfusion Injury