Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways
نویسندگان
چکیده
منابع مشابه
Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways
A renewed interest in the role of complement in the pathogenesis of glomerular diseases has improved our understanding of their basic, underlying physiology. All 3 complement pathways-classical, lectin, and alternative-have been implicated in glomerular lesions both rare (e.g., dense deposit disease) and common (e.g., IgA nephropathy). Here we review the basic function of these pathways and hig...
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The complement pathway is a central part of the innate immune system and also modulates adaptive immunity. It is implicated in the pathogenesis of glomerular disease by a number of clinical findings. These include the presence of complement components in renal biopsy samples, decreases in circulating levels indicating consumption, the presence of autoantibodies to complement proteins and the as...
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The complement system is part of the innate immune response that plays important roles in protecting the host from foreign pathogens. The complement components and relative fragment deposition have long been recognized to be strongly involved also in the pathogenesis of autoantibody-related kidney glomerulopathies, leading to direct glomerular injury and recruitment of infiltrating inflammation...
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2016
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2016.06.005