Complement Regulator–Acquiring Surface Protein 1 ofBorrelia burgdorferiBinds to Human Bone Morphogenic Protein 2, Several Extracellular Matrix Proteins, and Plasminogen

Available Findings Fail to Provide Strong Evidence of the Role of Bone Morphogenic Protein-2 in Femoral Head Osteonecrosis

Despite widespread research on non-traumatic femoral head osteonecrosis (FHON), there is no consensus about preventative treatment options. Insufficient blood supply and increased intra-osseous pressure are the initiating events in the majority of cases. BMPs are growth factors that belong to the transforming growth factor β (TGFβ) superfamily. Two specific formulations of BMPs have already bee...

Bone morphogenic protein receptor type 1a (BMPR1A) and Caveolin-1 associated with trastuzumab resistance of breast cancer cells

Trastuzumab is a specific monoclonal antibody used for therapeutic of the human epidermal growth factor receptor 2 (HER-2) -positive metastatic breast cancer. But, resistance to trastuzumab is a major obstacle in clinical efficiency.  During the past years, several studies have been done to find the mechanisms contributing to trastuzumab resistance. Previous studies have highlighted that bone m...

OmpL 1 is an extracellular matrix - and plasminogen - interacting protein of 1 Leptospira spp

3 4 Luis G. V. Fernandes; Monica L. Vieira; Karin Kirchgatter; Ivy J. Alves; Zenaide M. de 5 Morais; Silvio A. Vasconcellos; Eliete C. Romero and Ana L. T. O. Nascimento 6 7 8 Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503-900, São Paulo, SP, 9 Brazil; Interunidades em Biotecnologia, Instituto de Ciências Biomédicas, USP, São Paulo, Brazil; 10 Núcleo de Estudos e...

Adverse Effects of Bone Morphogenic Protein-2 during Osseointegration

RECOMBINANT HUMAN BONE MORPHOGENIC PROTEIN-2 (rhBMP-2) USE IN MAXILLOFACIAL SURGERY

Surgeons can now control osteogenesis through local application of BMP-2. BMP’s are osteoinductive proteins that are located in bone matrix and are responsible for embryonic skeletal formation and bone healing. Marshal Urist first coined the term “bone morphogenic protein” over 40 years ago. Recombinant human BMP-2 is an osteoinductive growth factor that has the potential to make autogenous bon...