Complete disproportionation of duplex poly(dT)middle dotpoly(dA) into triplex poly(dT)middle dotpoly(dA)middle dotpoly(dT) and poly(dA) by coralyne
نویسندگان
چکیده
منابع مشابه
Controlling nucleic acid secondary structure by intercalation: effects of DNA strand length on coralyne-driven duplex disproportionation.
Small molecules that intercalate in DNA and RNA are powerful agents for controlling nucleic acid structural transitions. We recently demonstrated that coralyne, a small crescent-shaped molecule, can cause the complete and irreversible disproportionation of duplex poly(dA)*poly(dT) into triplex poly(dA)*poly(dT)*poly(dT) and a poly(dA) self-structure. Both DNA secondary structures that result fr...
متن کاملNew aspects of the interaction of the antibiotic coralyne with RNA: coralyne induces triple helix formation in poly(rA)•poly(rU)
The interaction of coralyne with poly(A)*poly(U), poly(A)*2poly(U), poly(A) and poly(A)*poly(A) is analysed using spectrophotometric, spectrofluorometric, circular dichroism (CD), viscometric, stopped-flow and temperature-jump techniques. It is shown for the first time that coralyne induces disproportionation of poly(A)*poly(U) to triplex poly(A)*2poly(U) and single-stranded poly(A) under suita...
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Comparison of Duplex and Triplex Memory Reliability
A large number of choices exist when designing a reliable memory system. The choices range from simple replication to complex error control codes (ECC). An intermediate solution is to use combination of replication and simple ECC. Such a system consists of multiple memory modules, data stored in each module being encoded using an ECC. This paper compares reliability of memory systems formed usi...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2002
ISSN: 1362-4962
DOI: 10.1093/nar/30.4.983