Complex patterns of inheritance of an imprinted murine transgene suggest incomplete germline erasure
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چکیده
منابع مشابه
Germline transcription and recombination of a murine VDJμδγ1 transgene
To investigate the regulation of Ig switch recombination, we have constructed mice with a 56 kb VDJμδγ1 transgene. This transgene included an anti-nitrophenyl VDJ segment, Sμ, Cμ, Cδ, Iγ1, Sγ1, Cγ1 and the Cγ1 membrane exons from the murine Igha haplotype. Two founder lines were produced, with very similar characteristics. Transgenic B cells expressed normal amounts of Cμ (which is .95% transge...
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Long before genetics was established as a scientific discipline, fundamental questions on the nature of heredity in both plants and animals have engaged the human mind. For example, why do offspring share more of the physical characteristics of their parents than they do with unrelated members of their species? Why do members within one species share more traits than they do with members of ano...
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The patterns of transgene inheritance in plants and the possible explanations for non-Mendelian transmission are reviewed. The non-Mendelian inheritance of a transgene has been recorded with a frequency between 10% and 50% in transgenic plants produced either by Agrobacterium-mediated transformation or through particle bombardment. Different effects such as deletion, duplication, rearrangement,...
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abstract lexical knowledge of complex english words is an important part of language skills and crucial for fluent language use (nation, 2001). the present study, thus, was an attempt to assess the role of morphological decomposition awareness as a vocabulary learning strategy on learners’ productive and receptive recall and recognition of complex english words. so 90 sophomores (female and ma...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2000
ISSN: 1362-4962
DOI: 10.1093/nar/28.17.3301