Comprehensive Protein Profiling of Synovial Fluid in Osteoarthritis
نویسندگان
چکیده
منابع مشابه
Comprehensive protein profiling of synovial fluid in osteoarthritis following protein equalization
OBJECTIVE The aim of the study was to characterise the protein complement of synovial fluid (SF) in health and osteoarthritis (OA) using liquid chromatography mass spectrometry (LC-MS/MS) following peptide-based depletion of high abundance proteins. DESIGN SF was used from nine normal and nine OA Thoroughbred horses. Samples were analysed with LC-MS/MS using a NanoAcquity™ LC coupled to an LT...
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BACKGROUND Inflammation is associated with the onset and progression of osteoarthritis in multiple joints. It is well known that mechanical properties differ between different joints, however, it remains unknown if the inflammatory process is similar/distinct in patients with hip vs. knee OA. Without complete understanding of the role of any specific cytokine in the inflammatory process, unders...
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OBJECTIVE To investigate if the relative content of aggrecan and cartilage oligomeric matrix protein (COMP) in synovial fluid lavage samples differs between individuals with knee pain with or without evidence of radiological knee osteoarthritis (joint space narrowing). METHODS In a community based cohort of 204 individuals aged 35-54 years with chronic (> 3 months duration) knee pain, a subgr...
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CONTEXT Joint trauma is a risk factor for osteoarthritis (OA), which is becoming an increasingly important orthopedic concern for athletes and nonathletes alike. For advances in OA prevention, diagnosis, and treatment to occur, a greater understanding of the biochemical environment of the affected joint is needed. OBJECTIVE To demonstrate the potential of a biochemical technique to enhance ou...
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OBJECTIVES To determine concentrations of chondroitin sulphate (CS) disaccharides in knee synovial fluid (SF) from normal subjects and patients with osteoarthritis (OA) or rheumatoid arthritis (RA), to test whether these variables differ between different diseases and subsets of OA. METHODS OA was subdivided into large joint OA (LJOA), nodal generalised OA (NGOA), and OA with calcium pyrophos...
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ژورنال
عنوان ژورنال: Equine Veterinary Journal
سال: 2014
ISSN: 0425-1644
DOI: 10.1111/evj.12323_42