Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope
نویسندگان
چکیده
منابع مشابه
Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
Computational grafting of functional motifs onto scaffold proteins is a promising way to engineer novel proteins with pre-specified functionalities. Typically, protein grafting involves the transplantation of protein side chains from a functional motif onto structurally homologous regions of scaffold proteins. Using this approach, we previously transplanted the human immunodeficiency virus 2F5 ...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2012
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2011.10.003