Computational methods for chromosome-scale haplotype reconstruction
نویسندگان
چکیده
منابع مشابه
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The inference of haplotype pairs directly from unphased genotype data is a key step in the analysis of genetic variation in relation to disease and pharmacogenetically relevant traits. Most popular methods such as Phase and PL do require either the coalescence assumption or the assumption of linkage between the single-nucleotide polymorphisms (SNPs). We have now developed novel approaches that ...
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15 صفحه اولA Hidden Markov Technique for Haplotype Reconstruction
We give a new algorithm for the genotype phasing problem. Our solution is based on a hidden Markov model for haplotypes. The model has a uniform structure, unlike most solutions proposed so far that model recombinations using haplotype blocks. In our model, the haplotypes can be seen as a result of iterated recombinations applied on a few founder haplotypes. We find maximum likelihood model of ...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2021
ISSN: 1474-760X
DOI: 10.1186/s13059-021-02328-9