Computational models that predict response to HIV therapy can reduce virological failure and therapy costs in resource-limited settings
نویسندگان
چکیده
منابع مشابه
Computational models can predict response to HIV therapy without a genotype and may reduce treatment failure in different resource-limited settings.
OBJECTIVES Genotypic HIV drug-resistance testing is typically 60%-65% predictive of response to combination antiretroviral therapy (ART) and is valuable for guiding treatment changes. Genotyping is unavailable in many resource-limited settings (RLSs). We aimed to develop models that can predict response to ART without a genotype and evaluated their potential as a treatment support tool in RLSs....
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The global scale-up of antiretroviral treatment in past years has, unfortunately, not been accompanied by adequate strengthening of laboratory capacity. Monitoring of treatment with HIV viral load and resistance testing, as recommended in industrialized countries, is rarely available in resource-limited settings due to high costs and stringent requirements for storage and transport of plasma. C...
متن کاملPotential Impact of a Free Online HIV Treatment Response Prediction System for Reducing Virological Failures and Drug Costs after Antiretroviral Therapy Failure in a Resource-Limited Setting
OBJECTIVE Antiretroviral drug selection in resource-limited settings is often dictated by strict protocols as part of a public health strategy. The objective of this retrospective study was to examine if the HIV-TRePS online treatment prediction tool could help reduce treatment failure and drug costs in such settings. METHODS The HIV-TRePS computational models were used to predict the probabi...
متن کاملThe use of computational models to predict response to HIV therapy for clinical cases in Romania.
INTRODUCTION A major challenge in Romania is the optimisation of antiretroviral therapy for the many HIV-infected adults with, on average, a decade of treatment experience. The RDI has developed computational models that predict virological response to therapy but these require a genotype, which is not routinely available in Romania. Moreover the models, which were trained without any Romanian ...
متن کاملThe Determinants of HIV Treatment Costs in Resource Limited Settings
BACKGROUND Governments and international donors have partnered to provide free HIV treatment to over 6 million individuals in low and middle-income countries. Understanding the determinants of HIV treatment costs will help improve efficiency and provide greater certainty about future resource needs. METHODS AND FINDINGS We collected data on HIV treatment costs from 54 clinical sites in Botswa...
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ژورنال
عنوان ژورنال: Journal of the International AIDS Society
سال: 2012
ISSN: 1758-2652
DOI: 10.7448/ias.15.6.18114