Computer Simulation of Chromatin: Interdependency Between Nucleosome Positions and Chromatin Structure
نویسندگان
چکیده
منابع مشابه
Distal chromatin structure influences local nucleosome positions and gene expression
The positions of nucleosomes across the genome influence several cellular processes, including gene transcription. However, our understanding of the factors dictating where nucleosomes are located and how this affects gene regulation is still limited. Here, we perform an extensive in vivo study to investigate the influence of the neighboring chromatin structure on local nucleosome positioning a...
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Chromatin nucleosomes (mononucleosomes through pentanucleosomes) have been isolated by staphylococcal nuclease digestion of calf thymus nuclei. The peak value ellipticity is the same for all oligomers, 1900 deg cm2, mol"* at 280 nm, 23°C. The dh28Q,/dT vs T show a progressive increase in Tm of the main thermal band (73.5 C, monomer; 79 C, pentamer). Very small amounts of free DNA can be observe...
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A major question in chromatin biology is to what extent the sequence of DNA directly determines the genetic and chromatin organization of a eukaryotic genome? We consider two aspects to this question: the DNA sequence-specified positioning of nucleosomes and the determination of NDRs (nucleosome-depleted regions) or barriers. We argue that, in budding yeast, while DNA sequence-specified nucleos...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.2643