Concerning Trend in Ceftriaxone Minimum Inhibitory Concentration (MIC): Implications for the Treatment of Enteric Fever

Introduction:Salmonella typhi and paratyphi - related enteric fever still poses serious health risks to people all over the world. Ceftriaxone azithromycin were recommended as preferred treatments for following emergence of fluoroquinolone resistance. Several reports ceftriaxone resistance have also been reported, hence accurate medication susceptibility tracking is essential maintain empiric management fever. This study’s objective determine MIC in order help clinicians prescribe right dosage stop Material Methods: The investigation was carried out 800 bedded hospital Ghaziabad using a cross-sectional prospective design. A total 228 Salmonella isolates included this investigation. isolates’ antibiotic assessed Kirby Bauer disc diffusion method, calculated Broth Micro-Dilution (BMD) method. Result: Of species that isolated, 64 (28.07%) A, 164 (71.92%) Salmonellatyphi. found 33 (20.12%) Salmonellatyphi strains while it 14 (21.87%) S. strains. 0.125 μg/ml MIC50 value well but MIC90 8 4 isolates. Conclusion: revealed concerning rise reemergence sensitivity first-line medications.