Configurable High-Frequency Alternating Magnetic Field Generator for Nanomedical Magnetic Hyperthermia Applications

This article shows the use of a high-frequency Full-Bridge inverter to design an alternating magnetic field generator for experimental studies on anti-cancer treatment with nanoparticles. In hyperthermia, nanoparticles are used raise pathological cancerous cell's temperature high enough induce their death by apoptosis, but not as destroy them thermal ablation whole tissue volume, consequently leaving healthy cells alive. Conventionally, sinusoidal fields heat nanoparticles, which can be more easily produced than other waveforms. However, there no theoretical nor reasons choose waveform. work aims develop improved power system study effect different waveforms production when exciting aiming at demonstrating that much efficient in producing conventional sinusoids. To prove our hypothesis, we designed able generate four frequencies and fifth signal derived resonant capacitor, range 100 kHz 1 MHz up 10 mT peak intensity. Also, SiC devices process currents switching efficiently. Additionally, enhance efficiency, Zero-Voltage Switching is reduce losses minimize electromagnetic noise interference. The results obtained non-sinusoidal have shown remarkable performance improvement compared classical sine wave excitation. nanoparticles' dissipation depends applied field's slope, frequency, We conclude further deserves done find optimum conditions function particle biological environment test if this type could overcome system's performance.