Conformational stability as a design target to control protein aggregation
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چکیده
منابع مشابه
Conformational stability as a design target to control protein aggregation.
Non-native protein aggregation is a prevalent problem occurring in many biotechnological manufacturing processes and can compromise the biological activity of the target molecule or induce an undesired immune response. Additionally, some non-native aggregation mechanisms lead to amyloid fibril formation, which can be associated with debilitating diseases. For natively folded proteins, partial o...
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ژورنال
عنوان ژورنال: Protein Engineering, Design and Selection
سال: 2014
ISSN: 1741-0134,1741-0126
DOI: 10.1093/protein/gzu008