Congenital optic nerve anomalies and hereditary optic neuropathies

Oxydative Metabolism in Optic Nerve Myelin: New Perspectives in Hereditary Optic Neuropathies

ANT Adenosine Nucleotide Translocase; BSA Bovine Serum Albumin; CLSM Confocal Laser Scanning Microscopy; CNS Central Nervous System; EGTA Ethylene Glycol Tetraacetic Acid; ETC Electron Transport Chain; GA Glutaraldehyde; Ide, Idebenone; IM Isolated Myelin; MBP Myelin Basic Protein; LHON LeberHereditary Optic Neuropathy; MW MolecularWeight; NS Nervous System; OXPHOS Oxidative Phosphorylation; PB...

Medical Management of Hereditary Optic Neuropathies

Hereditary optic neuropathies are diseases affecting the optic nerve. The most common are mitochondrial hereditary optic neuropathies, i.e., the maternally inherited Leber's hereditary optic neuropathy (LHON) and dominant optic atrophy (DOA). They both share a mitochondrial pathogenesis that leads to the selective loss of retinal ganglion cells and axons, in particular of the papillo-macular bu...

The efficacy of optic nerve sheath decompression for anterior ischemic optic neuropathy and other optic neuropathies.

First proposed by De Wecker! in 1872 as a treatment for neuroretinitis, optic nerve sheath decompression (or fenestration) is an operation that has caused much controversy. This surgical therapy was not seriously considered until Davidson" and Smith, Hoyt, and Newton" reintroduced it in 1969 as an alternative therapy for chronic disk edema. Over the next 19 years, however, only about 60 cases o...

Mitochondrial optic neuropathies.

Strategies for optic nerve rescue and regeneration in glaucoma and other optic neuropathies.

Glaucoma is the most common age-related optic nerve disease and also the most common neuropathy, affecting approximately 60 million people worldwide in its most common forms. This figure is expected to rise to 80 million by 2020. Glaucoma is a neurodegenerative disease in which various triggers induce cascades of secondary events, which ultimately lead to apoptotic retinal ganglion cell (RGC) d...