Constitutive expression of a Mg2+-inhibited K+current and a TRPM7-like current in human erythroleukemia cells
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چکیده
منابع مشابه
Constitutive expression of a Mg2+-inhibited K+ current and a TRPM7-like current in human erythroleukemia cells.
Whole cell patch-clamp experiments were undertaken to define the basal K(+) conductance(s) in human erythroleukemia cells and its contribution to the setting of resting membrane potential. Experiments revealed a non-voltage-activated, noninactivating K(+) current. The magnitude of the current recorded under whole cell conditions was inhibited by an increase in free intracellular Mg(2+) concentr...
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Although understood to be ubiquitously expressed, the functional identification and significance of Mg(2+)-inhibited, nonspecific cation currents has been established in only a few cell types. Here we identified an outwardly rectifying nonspecific cation current in quiescent rat hepatocytes and the proliferating and polarized rat hepatoma, WIF-B. Under whole cell recording conditions in which c...
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Mishra R, Rao V, Ta R, Shobeiri N, Hill CE. Mg and MgATP-inhibited and Ca /calmodulin-sensitive TRPM7-like current in hepatoma and hepatocytes. Am J Physiol Gastrointest Liver Physiol 297: G687–G694, 2009. First published August 6, 2009; doi:10.1152/ajpgi.90683.2008.—Although understood to be ubiquitously expressed, the functional identification and significance of Mg -inhibited, nonspecific ca...
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Non-excitable cells use Ca2+ influx for essential functions but usually lack voltage-gated Ca2+ channels. The main routes of Ca2+ entry appear to be store-operated channels or Ca2+-permeable non-selective cation channels, of which the magnesium-inhibited cation (or magnesium-nucleotide-regulated metal cation) current has received considerable recent attention. This current appears to be produce...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2012
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00071.2011