Control of Citric Acid Cycle Activity in Rat Heart Mitochondria
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چکیده
منابع مشابه
Control of citric acid cycle activity in rat heart mitochondria.
Rat heart mitochondria were incubated in state 3 (with ADP) or state 4 (without ADP) in the presence of [3J4C]pyruvate, [3J4C]pyruvate plus unlabeled malate, or unlabeled pyruvate plus uniformly labeled [14C]malate. The net accumulation or loss of each intermediate in the citric acid cycle was determined by specific enzyme assays. In addition, the incorporation of radioactivity into cycle inter...
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Factors regulating the citric acid cycle have been investigated in rat heart mitochondria oxidizing pyruvate plus malate or acetylcarnitine plus malate as substrates. Effects caused by changing the NAD oxidation-reduction state, the intramitochondrial ATP:ADP ratio, and the respiratory rate were studied in five different metabolic states produced by additions of ADP, oligomycin, or uncouplers. ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1970
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)63427-1