Conversion from epoetin beta to darbepoetin: what is the equivalent dose?
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چکیده
منابع مشابه
Dose Conversion Ratio in Hemodialysis Patients Switched from Darbepoetin Alfa to PEG-Epoetin Beta: AFFIRM Study
INTRODUCTION There is limited information published on switching erythropoiesis-stimulating agent (ESA) treatment for anemia associated with chronic kidney disease (CKD) from darbepoetin alfa (DA) to methoxy polyethylene glycol-epoetin beta (PEG-Epo) outside the protocol of interventional clinical studies. AFFIRM (Aranesp Efficiency Relative to Mircera) was a retrospective, multi-site, observat...
متن کاملAntibody-mediated pure red cell aplasia (PRCA) on switching from darbepoetin alfa to epoetin beta: what are the implications?
We report the development of antibody-mediated pure red cell aplasia (PRCA) in a 63-year-old man with end-stage renal disease following a switch from darbepoetin alfa to epoetin beta. Haemoglobin levels began to decrease 6 months after the switch. Increasing the epoetin beta dose produced no response and regular blood transfusions were required; PRCA was confirmed and epoetin beta was discontin...
متن کاملDose–Conversion Ratio for Epoetin Alfa and Darbepoetin Alfa in Chemotherapy Patients with Anemia and Cancer
INTRODUCTION Anemia is a common complication of myelosuppressive chemotherapies in patients with cancer.1 When untreated, chemotherapy-induced anemia (CIA) may adversely affect the patient’s quality of life and ability to function because of symptoms such as fatigue, weakness, shortness of breath, and impaired mental function.2-4 Red blood cell (RBC) transfusions can be used to correct anemia, ...
متن کاملSwitch from epoetin to darbepoetin alfa in hemodialysis: dose equivalence and hemoglobin stability
AIM The objective of the study reported here was to describe dose equivalence and hemoglobin (Hb) stability in a cohort of unselected hemodialysis patients who were switched simultaneously from epoetin alfa to darbepoetin alfa. METHODS This was a multicenter, observational, retrospective study in patients aged ≥18 years who switched from intravenous (IV) epoetin alfa to IV darbepoetin alfa in...
متن کاملConversion from epoetin alfa to darbepoetin alfa: effects on patients' hemoglobin and costs to canadian dialysis centres.
BACKGROUND The erythropoiesis-stimulating agents epoetin alfa (EPO) and darbepoetin alfa (DPO) effectively treat the anemia that occurs in most patients undergoing hemodialysis. Published studies indicate that these 2 agents have similar efficacy and safety outcomes, but their relative costs in actual practice in Canada have not been extensively studied. OBJECTIVES To determine the relative u...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2008
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfn479