Core binding factor acute myelogenous leukemia-2021 treatment algorithm
نویسندگان
چکیده
منابع مشابه
Treatment of Acute Myelogenous Leukemia
There have been significant advances in our understanding of the biology of acute myelogenous leukemia (AML), and to a lesser extent, in its treatment. Dr. Estey has provided an excellent overview of the current state of the clinical management of the disease. He has described both the standard therapeutic approaches, including allogeneic hematopoietic stem cell transplantation, as well as the ...
متن کاملTreatment of acute myelogenous leukemia.
The treatment of patients with acute myelogenous leukemia (AML) ranges from palliative care only, to standard therapy, to investigational approaches. Acute myelogenous leukemia is, in fact, several different diseases, and the percentage of clinical responses varies with disease and prognostic subsets. A high proportion of AML patients remain refractory to primary treatment or relapse later. Thi...
متن کاملTreatment of Acute Myelogenous Leukemia
Therapeutic strategies are evolving for the treatment of patients with newly diagnosed acute myelogenous leukemia (AML), as well as for those with relapsed or refractory disease. Clinical and laboratory studies have demonstrated that AML is not a single disease, but a heterogeneous group of diseases with different clinical features and natural histories. There are variable responses to therapy ...
متن کاملStem Cell Modeling of Core Binding Factor Acute Myeloid Leukemia
Even though clonally originated from a single cell, acute leukemia loses its homogeneity soon and presents at clinical diagnosis as a hierarchy of cells endowed with different functions, of which only a minority possesses the ability to recapitulate the disease. Due to their analogy to hematopoietic stem cells, these cells have been named "leukemia stem cells," and are thought to be chiefly res...
متن کاملSNP-array lesions in core binding factor acute myeloid leukemia
Acute myeloid leukemia (AML) with t(8;21) and inv(16), together referred as core binding factor (CBF)-AML, are recognized as unique entities. Both rearrangements share a common pathophysiology, the disruption of the CBF, and a relatively good prognosis. Experiments have demonstrated that CBF rearrangements were insufficient to induce leukemia, implying the existence of cooperating events. To ex...
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ژورنال
عنوان ژورنال: Blood Cancer Journal
سال: 2021
ISSN: 2044-5385
DOI: 10.1038/s41408-021-00503-6