Coronavirus Genus Recognition Based on Prototype Virus Variants

Method named as variant approach to recognizing genus of coronavirus that is based on frequency codon distribution in viral ORF1ab and genes structural proteins (S, M N) was proposed the work. This method uses modified statistics whose efficiency demonstrated earlier for flavivirus species recognition. To recognize considers both various combinations several individual genes. Finally, determined result analysis all variants considered. The developed with help learning sample from prototype Alphacoronavirus, Betacoronavirus, Deltacoronavirus Gammacoronavirus genus. Application has high assurance at level 95 %. Among joint analysis, most reliability (98 %) been achieved if used. Variant revealed a phenomenon mosaic structure genomes, i.e., when results recognition few differ final conclusion about It seems such reflects homologous recombinations between coronaviruses plasticity their genomes evolutionary processes.