Correction: Corrigendum: Allelic variation contributes to bacterial host specificity

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Allelic variation contributes to bacterial host specificity

Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynonymous single-nucleotide polymorphisms (nsSNPs) has not been systematically evaluated. Here, our g...

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Allelic and Nonallelic Genes Controlling Host Specificity in a Bacteriophage.

ACTERIA infected with any two independently arising r (plaque type) B mutants of the bacterial virus T2H have been found, as a rule, to yield wild-type and double-mutant individuals among the viral progeny ( HERSHEY and ROTMAN 1948). This result has been interpreted in terms of recombination among nonallelic genetic-factors, and it is permissible to speak of the test in which bacteria are infec...

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Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders.

JAK2V617F is an acquired mutation associated with polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). We tested the hypothesis that the paradox of a single disease allele associated with 3 distinctive clinical phenotypes could be explained in part by host-modifying influences. We screened for genetic variation within 4 candidate genes involved in JAK-STAT si...

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Host controlled variation in bacterial viruses.

Passage through new hosts or new tissues is a widely used method for altering the properties of viruses. In some instances selection of spontaneous mutants has been demonstrated to be the mechanism causing the variation (Luria, 1945). Nonhereditary mechanisms sometimes have been postulated, but since no such case has been analyzed sufficiently, it is often assumed that selection of mutants is t...

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ژورنال

عنوان ژورنال: Nature Communications

سال: 2017

ISSN: 2041-1723

DOI: 10.1038/ncomms15229