Correlates of Protective Immunity to Mycobacterium tuberculosis in Humans
نویسندگان
چکیده
منابع مشابه
Correlates of protective immunity to Mycobacterium tuberculosis in humans.
Correlates of protective immunity to Mycobacterium tuberculosis in humans are desirable for identifying protective antigens, demonstrating the immunogenicity of a vaccine candidate and its potential efficacy, and permitting optimization of the dose, vehicle, adjuvant, and schedule of immunization. Potential correlates can be proposed on the basis of animal models and ex vivo/in vitro studies in...
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Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge. MTB has evolved a plethora of strategies to evade the immune response sufficiently to survive within the macrophage in a bacterial-immunological equilibrium, yet causes sufficient immunopathology to facilitate its transmission. This review highlights MTB as the driver...
متن کاملT cells and adaptive immunity to Mycobacterium tuberculosis in humans.
The adaptive immune response mediated by T cells is critical for control of Mycobacterium tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens and host T-cell responses that are required for an effective adaptive immune response to M. tuberculosis infection are yet to be defined. Here, we review recent findings on CD4(+) and CD8(+) T-cell responses to M. tub...
متن کاملImmunity to Mycobacterium tuberculosis
1Department of Infectious Diseases and Immunology, University of Sydney, Sydney, NSW 2000, Australia 2 Infectiologie Animale et Santé Publique, INRA Centre de Tours, Nouzilly 37380, France 3Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 4Centenary Institute of Cancer Medicine and Cell Biology, Newto...
متن کاملInnate immunity to Mycobacterium tuberculosis.
The different manifestations of infection with Mycobacterium tuberculosis reflect the balance between the bacillus and host defense mechanisms. Traditionally, protective immunity to tuberculosis has been ascribed to T-cell-mediated immunity, with CD4(+) T cells playing a crucial role. Recent immunological and genetic studies support the long-standing notion that innate immunity is also relevant...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2000
ISSN: 1537-6591,1058-4838
DOI: 10.1086/313874