Correlation between electrical activity and the size of rabbit sino-atrial node cells.
نویسندگان
چکیده
منابع مشابه
Pacemaker mechanism of porcine sino-atrial node cells.
In cardiac sino-atrial node (SAN) cells, time- and voltage-dependent changes in the gating of various ionic currents provide spontaneous, stable and repetitive firing of action potentials. To address the ionic nature of the species-dependent heart rate, action potentials and membrane currents were recorded in single cells dissociated from the porcine SAN, and compared with those from SAN cells ...
متن کاملChronotropic effect of nizofenone fumarate in rabbit sino-atrial node in vitro.
1. The effects of nizofenone fumarate were studied on the membrane potentials and currents of rabbit sino-atrial node preparations by means of the double-microelectrode voltage clamp method. 2. In spontaneously firing pacemaker cells, nizofenone (above 1 microM) decreased the heart rate. Above 3 microM, nizofenone reduced the maximum upstroke velocity, the amplitude of the action potential and ...
متن کاملAtrial tachycardia secondary to sino-atrial node reentry.
In one patient reprodncibk episodes of sMal tachyear(200 msec, control; 70 msec, atropine) and sustained dia conld be elicited via programmed atrial premature atrial tachycardia no longer could be elicited. These dcpoluizations. Evllodion of the elechpphysiologic studies mpport the concept that h a t t i a l reciprocation shldks suggested that the most tikely mechanism was can be a mechanism re...
متن کاملCurrent-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine
"Funny" (f-) channels have a key role in generation of spontaneous activity of pacemaker cells and mediate autonomic control of cardiac rate; f-channels and the related neuronal h-channels are composed of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel subunits. We have investigated the block of f-channels of rabbit cardiac sino-atrial node cells by ivabradine, a novel heart ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1996
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1996.sp021728