Correlation of FFR measured after DES implantation with clinical parameters and long-term clinical outcome

Abstract Introduction The role of fractional flow reserve (FFR) measured directly after drug eluting stent (DES) implantation (post-PCI FFR) is not clear in predicting major adverse cardiac events (MACE), and it known which clinical parameters affect post-PCI FFR. Aim We aimed to clarify the relationship between FFR parameters, long-term MACE determine best cut-off prediction. Method Patients who underwent measurement at our center March 2009 January 2021 were included. examined gender, age, hypertension, diabetes mellitus, hyperlipidemia, indication (acute (ACS) vs. chronic coronary syndrome (CCS)), diameter, in-stent restenosis vs de novo lesion category, proximal non-proximal location, LAD (vs. non-LAD) pre-PCI sought correlation target vessel-related (cardiovascular death (CVD), non-fatal myocardial infarction (MI), recurrent revascularization (TVR)). Optimal was determined by ROC curves. Results Post-PCI performed 500 arteries 434 patients. location (0.86 non-LAD 0.91, p<0.001), male gender (0.87 0.89, p=0.001), younger age (p=0.0215), smaller diameter (p=0.0028) lower (p=0.0006) proved be independent predictors FFR, no other parameter showed a significant with During median follow-up 37 months, 24 CVD, 15 MI 47 TVR occurred. Follow-up complete 96.2% There inverse (p<0.001). Diabetes mellitus (p=0.0024) (0.0356) also MACE. for total patient population, lesions 0.83 (p<0.0001), 0.88 (p=0.0091), respectively. Conclusion value result difference ACS CCS. PCI, are MACE-free survival. predict whole population lesions. Funding Acknowledgement Type funding sources: None.