Correlation of penicillin minimum inhibitory concentrations and penicillin zone edge appearance with staphylococcal beta-lactamase production
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چکیده
منابع مشابه
Correlation of penicillin minimum inhibitory concentrations and penicillin zone edge appearance with staphylococcal beta-lactamase production.
Production of staphylococcal beta-lactamase was shown to be correlated with penicillin G minimum inhibitory concentrations (MICs) of greater than 0.05 microgram/ml for 97% of the Staphylococcus aureus and 99% of the Staphylococcus epidermidis strains tested. However, it is important to note that of the isolates for which MICs were equal to or less than 0.05 micro/ml, a significant percentage (1...
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In competition assays for radiolabeled penicillin, penicillin-binding proteins (PBPs) 4, 7a, and 7b showed very high affinities for strong inducers of AmpC beta-lactamase. Loss of PBP 4 resulted in diminished inducibility. This suggests that if PBPs are involved in induction of AmpC beta-lactamase, there is probably a redundancy in function among the different PBPs.
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The minimum inhibitory concentrations of penicillin and minocycline were measured on 300 consecutive isolates of N. gonorrhoeae from patients attending the Nottingham treatment centre. 210 (70 per cent.) of these were fully sensitive to penicillin (MIC less than 0-1 mug./ml) and 89 per cent. were fully sensitive to minocycline (MIC less than 0-5 mug./ml.). Of the nine strains resistant to penic...
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The few reports from Africa on sensitivity determinations of Neisseria gonorrhoeae suggest that there is an increasing resistance in the strains, as has been found in other parts of the world. In the current study, the penicillin sensitivities and β-lactamase production of 80 consecutive strains of N. gonorrhoeae isolated from cases of acute urethritis in African men in Ibadan were studied. Of ...
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The rapid renal clearance of penicillin has made it difficult to maintain blood levels adequate to combat resistant organisms such as enterococci and many staphylococci. Diodrast (1), p-amino-hippurate (PAH) (2), benzoic acid (3), sodium benzoate (3, 4), and carinamide (5), have been found to block renal tubular excretion of penicillin with enhancement of blood levels. Of these compounds, only ...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 1981
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.14.4.437-440.1981