Correlation of serum alpha fetoprotein (AFP) and tumor size of hepatocellular carcinoma (HCC) in a tertiary care hospital of Peshawar

Introduction: Early diagnosis of Hepatocellular Carcinoma (HCC) by imaging and biochemical tests would be valuable in controlling morbidity mortality associated with this most common primary hepatic malignancy which is the third leading cause global cancer-related deaths. Objective: To determine an association between level serum Alpha Fetoprotein (AFP) size tumor (HCC).Materials & Methods: This cross-sectional descriptive study was conducted Rehman Medical Institute, Peshawar, Pakistan from January 2018 till December 2019. Data were gathered medical records Endoscopy Unit Institute. Patients separated into three groups on basis AFP levels: Group I had standard levels (<20 IU/ml), II moderately raised (20-399 III significantly (>400 IU/ml). also tumor; A less than 3 cm, B it 5 C greater cm. For categorical variables, Chi-square Z test for proportions applied; Wilcoxon Rank-Sum (Mann-Whitney) used to evaluate variation two categories, Kruskal-Wallis Rank difference categories. p value ≤0.05 taken as significant. Descriptive statistics obtained SPSS 24. Result: total 136 patients evaluated according levels. The male female ratio 2.31:1. mean presenting age 59.36 ± 9.85 years while 6.93 4.39 Regarding groups, there 50(36.76%), I, 31(22.79%) 38(27.94%) III. As per Child Pugh classification, Class A, 69.85%, 16.18% 0% respectively.Conclusion: Serum alpha fetoprotein HCC size. can a helpful marker detect differentiate its initial late stages. Monitoring could useful diagnose recurring disease tumors that produce AFP.Keywords: Fetoprotein; Carcinoma; Tumor