Correlative study on the JAK-STAT/PSMβ3 signal transduction pathway in asthenozoospermia

Correlative study on the JAK-STAT/PSMβ3 signal transduction pathway in asthenozoospermia

The aim of the present study was to investigate the possible mechanism of Janus kinase (JAK)-signal transduction and activator of transcription (STAT)/PSMβ3 signaling in the occurrence of asthenozoospermia. We examined seminal fluid samples from 30 cases of asthenozoospermia and 30 healthy controls. Sperm was collected using the Percoll density gradient centrifugation method. The expression of ...

The Jak-STAT Signal Transduction Pathway in Melanoma

Computer Modeling of JAK/STAT Signal Transduction Pathway

Cytokines regulate important cellular responses through signal transduction pathways. The computer modeling is a useful method to understand dynamic characteristics or regulatory mechanisms of signal transduction pathways. The ultrasensitivity of the mitogen-activated protein kinase cascade was shown by the simulation study [2]. Many cytokine receptors transduce signals by receptor bound JAK ki...

On the Stochastic Modeling of the JAK-STAT Signal Transduction Pathway

At the level of individual cells, signaling is crucial for decisions about division, specialization, death and metabolic control. For more advanced organisms, it controls growth, development, behavior and metabolism; defective signaling is therefore at the origin of many diseases, like cancer, diabetes and developmental illnesses. Here we propose a stochastic framework based on multivariate non...

Urokinase activates the Jak/Stat signal transduction pathway in human vascular endothelial cells.

Endothelial cells demonstrate high urokinase expression and upregulation of urokinase receptors in response to vascular injury. Urokinase receptor binding facilitates endothelial cell migration into an arterial wound; however, the signaling cascade induced by the urokinase receptor in this cell type is incompletely understood. Because the Janus kinase (Jak)/signal transducer and activator of tr...