Cost-effectiveness of a fixed-dose combination agent in high-risk hypertensive patients

Efficacy and Safety of a Lercanidipine/Enalapril Fixed-Dose Combination in Hypertensive Patients in Portugal

BACKGROUND Fixed-dose combinations of hypertensive drugs have been advocated as a suitable option for hypertensive patients who require two or more drugs to achieve blood pressure (BP) targets. OBJECTIVES Our objective was to assess the efficacy and safety of lercanidipine/enalapril in clinical practice. METHODS This observational study collected data for patients with hypertension treated ...

Economic impact of switching to fixed-dose combination therapy for Japanese hypertensive patients: a retrospective cost analysis

BACKGROUND The prescription of fixed-dose combinations (FDC) of antihypertensive drugs has increased rapidly since the relaxation of the prescription-term restriction. In this study, we used the opportunity of this policy change in Japan as an instrument to assess the causal impact of switching to FDC on hypertensive treatment costs. METHODS Claims data from 64 community pharmacies located in...

Compliance and fixed-dose combination therapy in a sample of greek hypertensive patients.

Compliance and Fixed-Dose Combination Therapy in a Sample of Greek Hypertensive Patients AthAnAsiA K. PAPAzAfiroPoulou, Alexios sotiroPoulos, KyriAKos souliotis, GeorGe PArchAridis, GeorGe deliGiAnnis, GeorGe GionAKis, stefAnos PAPoulis, eystAthios sKliros Hellenic Association of Research and Continuing Education in Primary Care, Athens, Third Department of Internal Medicine and Center of Diabe...

Pharmacokinetics of Different Formulations of Telmisartan/amlodipine Fixed-dose Combination in Hypertensive Patients

Fixed dose combination of perindopril and indapamide improves peripheral vascular function in essential hypertensive patients.

BACKGROUND The effect on endothelium-dependent and independent vasodilation of 24-week treatment with a fixed-dose combination of perindopril/indapamide (2/0.625 mg, daily) and atenolol (50 mg, daily), was evaluated in 62 untreated essential hypertensive patients according a double-blind, parallel group, randomized study. METHODS Brachial artery flow-mediated dilation (FMD), response to subli...