Cotinine Effects on Peripheral Nerve Injuries: An Experimental Study
نویسندگان
چکیده
Aim: Cigarette smoking is a common addictive manner and one of the greatest threats to health. Nicotine main components cigarette. The aim this study was reveal effect cotinine which an active metabolite nicotine, on peripheral nerve injury in rats. Material Methods: We studied 42 male adult albino-Wistar rats that were divided into three groups with simple randomization method. Group 1 given Cotinine® (C-5923-sigma) intraperitoneally, at dose 0.3 mg/kg/day for 21 days. 2 ethyl alcohol, solvent Cotinine same way, period. 3 subjected sciatic compression by clip, has closing pressure 50 gr/cm2. type end Four weeks later after trauma, both sacrificed injured sections are taken histopathological analysis. Results: It observed aggravated traumatic degeneration as privileged caused fibrosis. In Schwann cells thick-myelinated fibers exhibited higher grades mitochondrial augmentation. According multiple comparison results, number Wallerian degenerations trauma group significantly lower than drug-control (p=0.016) drug (p<0.001) groups. This situation estimated response oxidative stress. Conclusion: reveals regeneration may be affected negatively smokers.
منابع مشابه
Biochemical and histopathological effects of catechin on experimental peripheral nerve injuries.
AIM Catechin is a type of polyphenol, along with epicatechin, epigallocatechin, and epigallocatechin-gallate (EGCG). This study aims to investigate the effect of EGCG, a major metabolite of catechin, which is the principle bioactive compound in green tea, on rats with peripheral nerve injury. MATERIAL AND METHODS A total of 74 rats were divided into six groups, namely the control, the trauma,...
متن کاملPreventing perioperative peripheral nerve injuries.
Peripheral nerve injuries are largely preventable injuries that can result from incorrect patient positioning during surgery. Patients who are diabetic, are extremely thin or obese, use tobacco, or undergo surgery lasting more than four hours are at increased risk for developing these injuries. When peripheral nerve injuries occur, patients may experience numbness, burning, or tingling and may ...
متن کاملExperimental and clinical study on peripheral nerve allografting.
There are numerous factors that affect the success of peripheral nerve grafting. Among these are (1) the type of injury to the nerve; (2) the degree of damage to the sur rounding tissue and its complications; (3) the general condition of the patient; (4) the age of the patient; (5) the size, level and location of the nerve defect; (6) the local nutrition and the amount of scar in and around the...
متن کاملTear-gas injuries. A clinical study of hand injuries and an experimental study of its effects on peripheral nerves and skeletal muscles in rabbits.
متن کامل
Homeopathic treatment for peripheral nerve regeneration: an experimental study in a rat sciatic nerve transection model.
AIM Effects of homeopathic treatment with Hypericum perforatum (Hypericum) on peripheral nerve regeneration was studied using a rat sciatic nerve transection model. METHODS Fifty-four male healthy White Wistar rats were divided into three experimental groups (n = 18), randomly: Sham-operation (Sham), control: silicon tube (Sil) and treatment: silicon tube + Hypericum (Sil/Hypericum). In the S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Duzce Universitesi Tip Fakültesi Dergisi
سال: 2021
ISSN: ['1307-671X']
DOI: https://doi.org/10.18678/dtfd.892654