Coverage and efficiency in current SNP chips
نویسندگان
چکیده
منابع مشابه
Efficiency and Power as a Function of Sequence Coverage, SNP Array Density, and Imputation
High coverage whole genome sequencing provides near complete information about genetic variation. However, other technologies can be more efficient in some settings by (a) reducing redundant coverage within samples and (b) exploiting patterns of genetic variation across samples. To characterize as many samples as possible, many genetic studies therefore employ lower coverage sequencing or SNP a...
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Chip-based high-throughput genotyping has facilitated genome-wide studies of genetic diversity. Many studies have utilized these large data sets to make inferences about the demographic history of human populations using measures of genetic differentiation such as F(ST) or principal component analyses. However, the single nucleotide polymorphism (SNP) chip data suffer from ascertainment biases ...
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The field of genetics has come to rely heavily on commercial genotyping arrays and accompanying annotations for insights into genotype-phenotype associations. However, in order to avoid errors and false leads, it is imperative that the annotation of SNP chromosomal positions is accurate and unambiguous. We report on genomic positional discrepancies of various SNP chips for human, cattle and mou...
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SNP chips are transforming animal breeding; low cost “assay-by-sequencing” methodologies and high quality reference genome sequences provide the opportunity for further significant improvement in both breeding and management. The Functional Annotation of ANimal Genomes (FAANG) consortium is applying methods developed by the human ENCODE project to annotate the genomes of livestock (sheep, cattl...
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Abstract Quiescent Signal Analysis (QSA) is a novel electrical-test-based diagnostic technique that uses IDDQ measurements made at multiple chip supply pads as a means of locating shorting defects in the layout. The use of multiple supply pads reduces the adverse effects of leakage current by scaling the total leakage current over multiple measurements. In previous work, a resistance model for ...
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ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2014
ISSN: 1018-4813,1476-5438
DOI: 10.1038/ejhg.2013.304