Cross-reactive binding versus selective phosphate sensing in an imine macrocycle sensor
نویسندگان
چکیده
Summary We demonstrate a new approach to chemosensors suited for analysis of phosphate mixtures. Here, combination cross-reactive receptor and an environmentally sensitive fluorophore allows binding various phosphates obtaining analyte-specific fluorescence response. have investigated flexible imine-pyrrole macrocycle comprising both hydrogen-bond donors acceptors, one that is capable self-organizing in response phosphate-type anions. This was elucidated by theoretical nuclear magnetic resonance (NMR) studies. Incorporating dansyl fluorophore, which responds the presence analytes with varying degree amplification, resulted translating into variable analyte enabled differentiation oxyanions. The trend anion affinities H2PO4?>AMP>H2P2O72?>ADP>ATP. show only sensor can differentiate among including their By applying machine learning algorithms, we were able between 12 anions accurately quantify ATP, ADP, AMP, PPi, Pi,
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ژورنال
عنوان ژورنال: Chem
سال: 2022
ISSN: ['2451-9308', '2451-9294']
DOI: https://doi.org/10.1016/j.chempr.2022.05.010