Cryptococcal-related Mortality Despite Fluconazole Preemptive Treatment in a Cryptococcal Antigen Screen-and-Treat Program
نویسندگان
چکیده
منابع مشابه
Disseminated cryptococcal infection despite treatment for cryptococcal meningitis.
Case Reports (Dr R F Miller) Case 1 A 25 year old Caucasian heterosexual man was found to be HIV I antibody positive in July 1989, when he presented to another hospital with cryptococcal meningitis. At this time his CD4+ count was 190 (normal range = 350-2,200)/mm3. Investigations showed normal urea and electrolyte levels and liver function tests; CT of the head was normal. Blood and urine cult...
متن کاملFluconazole-resistant cryptococcal meningitis.
A 40-year-old HIV-positive man was admitted to Cecilia Makiwane Hospital in December 2001 with a history of severe headache, photophobia and fever. Indian ink staining of cerebrospinal fluid (CSF) revealed yeast cells with 3 5 budding forms per high-power field. A diagnosis of cryptococcal meningitis was made and the patient was started on amphotericin B. He reacted to this almost immediately, ...
متن کاملPrevalence of Cryptococcal Antigenemia and Cost-Effectiveness of a Cryptococcal Antigen Screening Program – Vietnam
BACKGROUND An estimated 120,000 HIV-associated cryptococcal meningitis (CM) cases occur each year in South and Southeast Asia; early treatment may improve outcomes. The World Health Organization (WHO) recently recommended screening HIV-infected adults with CD4<100 cells/mm(3) for serum cryptococcal antigen (CrAg), a marker of early cryptococcal infection, in areas of high CrAg prevalence. We ev...
متن کاملSpontaneous Cryptococcal Peritonitis Successfully Treated with Fluconazole
Spontaneous cryptococcal peritonitis is an uncommon infection that predominantly encountered in immunocompromised. Its clinical presentation is indistinguishable from spontaneous bacterial peritonitis and often results in fatal outcome. Liver disease is an under recognized predisposition for cryptococcal disease. We report a case of spontaneous cryptococcal peritonitis in HIV-negative, non-diab...
متن کاملCombined therapy with fluconazole and flucytosine in murine cryptococcal meningitis.
To assess the possible beneficial effects of combined therapy (fluconazole and flucytosine) in the treatment of cryptococcal meningitis in the immunocompromised host, we compared therapy with fluconazole and flucytosine, individually and combined, in the experimental murine model. BALB/c athymic (nu/nu) mice were infected intracerebrally with 150 to 300 CFU of Cryptococcus neoformans. In mortal...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2019
ISSN: 1058-4838,1537-6591
DOI: 10.1093/cid/ciz485