Cryptococcus neoformans UGT1encodes a UDP-Galactose/UDP-GalNAc transporter
نویسندگان
چکیده
منابع مشابه
Cryptococcus neoformans.
Seven nonencapsulated mutants of Cryptococcus neoformans were isolated from an encapsulated strain of human origin. Initially, the mutants were avirulent for mice. After several months of subculturing, six of the seven isolates reverted LO the encapsulated state and possessed varying degrees of virulence. The results of these experiments suggest that a strong correlation exists between the pres...
متن کاملFunctional cloning and characterization of a UDP- glucuronic acid decarboxylase: the pathogenic fungus Cryptococcus neoformans elucidates UDP-xylose synthesis.
UDP-xylose is a sugar donor required for the synthesis of diverse and important glycan structures in animals, plants, fungi, and bacteria. Xylose-containing glycans are particularly abundant in plants and in the polysaccharide capsule that is the major virulence factor of the pathogenic fungus Cryptococcus neoformans. Biosynthesis of UDP-xylose is mediated by UDP-glucuronic acid decarboxylase, ...
متن کاملEcology of Cryptococcus neoformans.
Cryptococcus neoformans is a basidiomycetous, yeast-like fungus which, following inhalation from an environmental source, causes respiratory and neurological disease in humans and animals. Though the ecology of C. neoformans is poorly understood, recent observations provide clues about its life-cycle in nature. Two biotypes of C. neoformans are recognised, C. neoformans var. neoformans (serotyp...
متن کاملCryptococcus neoformans Strains
We examined the ploidy of C. neoformans strains using both laser scanning cytometry and a fluorescence microscope equipped with a photomultiplier. Haploid strains consisted of normal-sized cells with a haploid DNA amount. In the cell population there were also large-sized cells with a diploid DNA amount. These large cells in haploid strains were isolated using a Skerman micromanipulator, cultiv...
متن کاملMicromorphology of Cryptococcus neoformans.
Fine details of the internal and external morphology of Cryptococcus neoformans as seen in ultrathin sections are described and illustrated with electron micrographs. The capsule characteristic of this species contained microfibrils (30 to 40 A in diameter) that appeared to radiate from the cell wall and to coil and intertwine in various directions. These thin, uniformly structured, electron-de...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 2016
ISSN: 0959-6658,1460-2423
DOI: 10.1093/glycob/cww078