Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40
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چکیده
منابع مشابه
Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40 in the tumorigenicity of human melanoma cells (Ledda
in the tumorigenicity of human melanoma cells (Ledda Erhard Hohenester1, Patrik Maurer2,3 and et al., 1997). Other activities of BM-40 include calciumRupert Timpl2 dependent binding to collagens and thrombospondin, bindDepartment of Crystallography, Birkbeck College, ing to platelet-derived growth factor (PDGF)-AB and London WC1E 7HX, UK and 2Abteilung Proteinchemie, -BB and the regulation of c...
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Calcium binding and signaling orchestrate a wide variety of essential cellular functions, many of which employ the EF-hand Ca2+ binding motif. The ion binding parameters of this motif are controlled, in part, by the structure of its Ca2+ binding loop, termed the EF-loop. The EF-loops of different proteins are carefully specialized, or fine-tuned, to yield optimized Ca2+ binding parameters for t...
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The EF-hand motif is the most common calcium-binding motif found in proteins. Several high-resolution structures containing different metal ions bound to EF-hand sites have given new insight into the modulation of their binding affinities. Recently determined structures of members of several newly identified protein families that contain the EF-hand motif in some of their domains, as well as of...
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The EF-hand protein with a helix-loop-helix Ca(2+) binding motif constitutes one of the largest protein families and is involved in numerous biological processes. To facilitate the understanding of the role of Ca(2+) in biological systems using genomic information, we report, herein, our improvement on the pattern search method for the identification of EF-hand and EF-like Ca(2+)-binding protei...
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A 40-kDa sexual stage radiolabeled surface protein of Plasmodium falciparum, Pfs40, was previously identified as a potential target antigen of transmission blocking immunity by an immunogenetic approach. Synthetic oligonucleotide "guessmers," based on microsequenced tryptic peptides of Pfs40 purified by two-dimensional gel electrophoresis, were used to clone the full length cDNA and genomic DNA...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1997
ISSN: 0261-4189,1460-2075
DOI: 10.1093/emboj/16.13.3778