Crystal Structure of Clobetasol Propionate
نویسندگان
چکیده
منابع مشابه
Formulation, Optimization and Evaluation of Clobetasol Propionate Gel
Objective: The present study was aimed to develop topical gel of Clobetasol propionate with the help of carbopol-934 and Hydroxypropyl methylcellulose K4m as gelling agents. Polymers play major role in various characterization parameters of topical gel such as in vitro release and rheological properties. Methods: Gels were prepared with carbopol-934 and Hydroxypropyl methylcellulose K4m as gell...
متن کاملObservations on the systemic effect of topical clobetasol propionate (Dermovate).
Topical application of clobetasol propionate in a strength of 0-05% in cream or ointment (Dermovate) suppressed the hypothalamic-pituitary-adrenal axis in both normal people and patients with diseased skin. In normal people the 9 am serum cortisol level was suppressed when between 45 and 90 g was applied weekly. Insulin stress test results in patients with diseased skin showed an abnormally sma...
متن کاملEffect on adrenal function of topically applied clobetasol propionate (Dermovate).
Thirty-nine patients (15 outpatients and 24 inpatients) with a variety of skin diseases affecting variable areas of the body surface were treated with clobetasol propionate ointment (Dermovate). Before and after treatment the adrenal response to an intramuscular injection of tetracosactrin was rested and additional 9 am plasma cortisol levels were measured at intervals during treatment. A satis...
متن کاملDifferent Approaches for Improving Skin Accumulation of Clobetasol-17-propionate
INTRODUCTION Topical glucocorticoids (TG) are the most frequently prescribed drugs by dermatologists. Their clinical effectiveness in the treatment of psoriasis and atopic dermatitis is related to their vasoconstrictive, anti-inflammatory, immunosuppressive and anti-proliferative effects. Despite their benefit in the therapy of inflammatory diseases, TG are associated number of side effects tha...
متن کاملCushing's syndrome and pituitary-adrenal suppression due to clobetasol propionate.
Widespread application of clobetasol propionate resulted in suppression of the hypothalamic pituitary axis in four patients. Three patients showed Cushigoid features and developed symptoms of adrenocortical insufficiency on withdrawal of clobetasol.
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ژورنال
عنوان ژورنال: Analytical Sciences: X-ray Structure Analysis Online
سال: 2003
ISSN: 1348-2238
DOI: 10.2116/analscix.19.x37