Crystallite dissolution in PEO-based polymers induced by water sorption

Thermodynamics of water sorption in high performance glassy thermoplastic polymers

Sorption thermodynamics of water in two glassy polymers, polyetherimide (PEI) and polyetheretherketone (PEEK), is investigated by coupling gravimetry and on line FTIR spectroscopy in order to gather information on the total amount of sorbed water as well as on the different species of water molecules absorbed within the polymers, addressing the issue of cross- and self-interactions occurring in...

Improvement of Dissolution Characteristics and Bioavailability of Tadalafil by Solid Dispersion Technique Using Water-soluble Polymers

The enhancement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Tadalafil a BCS class II drug is an impotence agent. It is indicated for the treatment of erectile dysfunction and is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE-5).However, insolubility and poor dissolut...

Hydrogels by Stereo-complexation of Water-soluble Plla-peo-plla and Pdla-peo-pdla Triblock- Copolymers

s / Journal of Controlled Release 72 (2001) 225 –309 247 Introduction Biotechnology has evolved to the point that it is possible to prepare therapeutic genes for most diseases. The use of these new medicines is hampered by the lack of a suitable carrier system that helps the DNA in reaching the target cells and in the intracellular trafficking. Cationic polymers have been proposed as vectors fo...

Geochemistry of Uranium at Mineral-water Interfaces: Rates of Sorption-desorption and Dissolution-precipitation Reactions

Water Vapor Sorption and Diffusion in Secondary Dispersion Barrier Coatings: A Critical Comparison with Emulsion Polymers.

The conventional method for synthesizing waterborne polymer colloids is emulsion polymerization using surfactants. An emerging method is the use of secondary dispersions (SD) of polymers in water, which avoids the addition of any surfactant. Although there are numerous studies of the water barrier properties (sorption, diffusion, and permeability) of waterborne emulsion (Em) polymer coatings, t...