C‐type lectin‐like CD161 is not a co‐signalling receptor in gluten‐reactive CD4 + T cells

C-type lectin-like CD161, a class II transmembrane protein, is surface receptor expressed by NK cells and T cells. In coeliac disease, CD161 was more frequently on gluten-reactive CD4 + compared to other memory isolated from the same tissue compartment. putative co-signalling molecule that proposed act as co-stimulatory in context of signalling through TCR, but contradicting results were published. order understand role cells, we combined cell stimulation assays or proliferation with ligation intracellular cytokine staining. We found provided neither nor co-inhibitory signals modulate IFN-γ IL-21 production clones. Thus, suggest does not function